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Home / Primary Antibodies

BMP10 Antibody

SKU : BHA10558278

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA198870
Alternative Names	BMP-10; BMP10; Bone morphogenetic protein 10; MGC126783;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.Celeste A.J., Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.Hillier L.W., Nature 434:724-731(2005).Mazerbourg S., J. Biol. Chem. 280:32122-32132(2005).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human BMP10.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Celeste A.J., Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. Hillier L.W., Nature 434:724-731(2005). Mazerbourg S., J. Biol. Chem. 280:32122-32132(2005).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total BMP10 protein.
Subcellular Location	Secreted

Uniprot	O95393
Database Links	HGNC:20869 OMIM:608748 KEGG:hsa:27302 STRING:9606.ENSP00000295379 UniGene:Hs.158317
Function	Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Protein Families	TGF-beta family
Tissue Specificity	Detected in mammary epithelia (at protein level).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558278	CSB-PA198870	100ul	$297		Add to Cart

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