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Home / Primary Antibodies

Beta-TrCP Antibody / BTRC (F54622)

SKU : BHA17103089

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Mfr.No.	F54622, F54622-0.08ML, F54622-0.4ML
Antigen	Beta-TrCP
Clonality	Polyclonal
Description	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 17-52 from the human protein was used as the immunogen for the Beta-TrCP antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No
Subcellular Location	Cytoplasmic, nuclear

Uniprot	Q9Y297

Format	Purified
Purification	Antigen affinity purified
Storage	Aliquot the Beta-TrCP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC-P, WB
Dilution	Immunofluorescence: 1:25, Immunohistochemistry (FFPE): 1:25, Western blot: 1:500-1:2000

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17103089-1	F54622-0.08ML	0.08ml	$165		Add to Cart
BHA17103089-2	F54622-0.4ML	0.4ml	$379		Add to Cart

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