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Home / Primary Antibodies

Beta Catenin Antibody (V8966SAF)

SKU : BHA17122999

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NSJ Bioreagents

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Mfr.No.	V8966SAF-100UG
Clonality	Recombinant Mouse Monoclonal
Description	Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic patte. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining patte observed with lobular breast carcinomas.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Recombinant full-length human Beta-Catenin/CTNNB1 protein was used as the immunogen for the recombinant Catenin Beta antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the recombinant Catenin Beta antibody should be determined by the researcher.

Uniprot	P35222

Format	Purified
Purity	Protein A/G affinity
Storage	Aliquot the recombinant Catenin Beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17122999	V8966SAF-100UG	100ug	$499		Add to Cart

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