The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. (RefSeq)
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
Chicken b-Catenin was used as the immunogen for the b-Catenin antibody.
Isotype
Mouse IgG1, kappa
Species Reactivity
Human
Note
Titration of the b-Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
P35222
Format
Purified
Purity
Protein G affinity chromatography
Storage
Store the b-Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).