Beta Arrestin 2 is an intracellular protein that in humans is encoded by the ARRB2 gene. Members of the arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptorfunction in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Beta-arrestins were originally discovered in the context of heterotrimeric G protein-coupled receptor desensitization, but they also function in internalization and signaling of these receptors.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human ARRB2 (RLKGMKDDDYDDQLC) was used as the immunogen for this Beta Arrestin 2 antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Uniprot
P32121
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the Beta Arrestin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
WB, IHC-P
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml