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Home / Primary Antibodies

Beta Arrestin 1 Antibody (F54014)

SKU : BHA17119913

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NSJ Bioreagents

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Mfr.No.	F54014-0.1ML
Clonality	Monoclonal (mouse origin)
Description	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for intealization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. (UniProt)
Formulation	Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host	Mouse
Immunogen Region	A human recombinant protein was used as the immunogen for this Beta Arrestin 1 antibody.
Isotype	Mouse IgG2b
Species Reactivity	Human
Note	The stated application concentrations are suggested starting points. Titration of the Beta Arrestin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Uniprot	P49407

Format	Purified
Purity	Protein G affinity
Storage	Store the Beta Arrestin 1 antibody at -20oC.

Applications	WB
Description	Weste blot: 1:500

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119913	F54014-0.1ML	0.1 ml	$379		Add to Cart

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