Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.Gibson L., Oncogene 13:665-675(1996).Nagase T., DNA Res. 3:321-329(1996).O'Reilly L.A., Cell Death Differ. 8:486-494(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human BCLW.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Gibson L., Oncogene 13:665-675(1996). Nagase T., DNA Res. 3:321-329(1996). O'Reilly L.A., Cell Death Differ. 8:486-494(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total BCLW protein.
Subcellular Location
Mitochondrion membrane, Peripheral membrane protein
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Protein Families
Bcl-2 family
Tissue Specificity
Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or li
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.