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Home / Antibodies

BAX (Ab-167) Antibody

SKU : BHA10559106

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA834415
Alternative Names	Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Oltvai Z.N., Cell 74:609-619(1993).Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001).Guo B., Nature 423:456-461(2003)
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Bax around the phosphorylation site of threonine 167 (F-G-T(p)-P-T).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Oltvai Z.N., Cell 74:609-619(1993). Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001). Guo B., Nature 423:456-461(2003)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Bax protein
Subcellular Location	Isoform Alpha: Mitochondrion membrane, Single-pass membrane protein, Cytoplasm

Uniprot	Q07812
Gene Id	581
Database Links	HGNC:959 OMIM:600040 KEGG:hsa:581 STRING:9606.ENSP00000293288 UniGene:Hs.624291
Function	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Pathway	p53 signaling pathway Apoptosis Necroptosis Protein processing in endoplasmic reticulum AGE-RAGE signaling pathway in diabetic complications Neurotrophin signaling pathway
Protein Families	Bcl-2 family
Tissue Specificity	Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lu
Weight	21,184 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559106	CSB-PA834415	100ul	$297		Add to Cart

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