Rabbit Anti-Human Bassoon Polyclonal

Mfr.No.	SPC-198, SPC-198D, SPC-198D-A390, SPC-198D-A488, SPC-198D-A594, SPC-198D-ALP, SPC-198D-APC, SPC-198D-BI, SPC-198D-FITC, SPC-198D-HRP, SPC-198D-PCP, SPC-198D-RPE, SPC-198S
Immunogen Species	Human
Alternative Names	BSN Antibody, ZNF231 Antibody, Neuronal double zine finger protein Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Cell Junction, Synapse
Certificate Of Analysis	1 ug/ml of SPC-198 was sufficient for detection of Bassoon in 10 ug of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Bassoon Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein, Homo Sapiens (Human)
Immunogen Region	NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein of human Bassoon
Launch Date	2011/03/22
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q9UPA5
Accession Number	NP_003449.2
Gene Id	8927
Target	Bassoon
Research Area	Multiple System Atrophy, Cell Markers, Neuron Markers, Presynaptic Markers, Neurodegeneration, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), IHC (1:400); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~420kDa. Multiple isoforms can be detected.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB
Description	WB ; IHC
Dilution	WB (1:1000), IHC (1:400); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Anna Dondzillo et al., (2010) J. Comp Neur, 518(7): 10081029.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11907357-1	SPC-198D	Unconjugated	100 ug	$330	Add to Cart
BHA11907357-2	SPC-198D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11907357-3	SPC-198D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11907357-4	SPC-198D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11907357-5	SPC-198D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11907357-6	SPC-198D-APC	APC	100 ug	$382	Add to Cart
BHA11907357-7	SPC-198D-BI	Biotin	100 ug	$378	Add to Cart
BHA11907357-8	SPC-198D-FITC	FITC	100 ug	$374	Add to Cart
BHA11907357-9	SPC-198D-HRP	HRP	100 ug	$370	Add to Cart
BHA11907357-10	SPC-198D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11907357-11	SPC-198D-RPE	RPE	100 ug	$380	Add to Cart
BHA11907357-12	SPC-198S	Unconjugated	12 ug	$44	Add to Cart

Bassoon Antibody - SPC-198