BAG family molecular chaperone regulator 4; BAG-4; BAG-family molecular chaperone regulator-4; BAG4; Bcl-2-associated athanogene 4
Categories
Primary Antibodies
Clonality
polyclonal
Description
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release By similarity. Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.Takayama S., J. Biol. Chem. 274:781-786(1999).Jiang Y., Science 283:543-546(1999).Briknarova K., J. Biol. Chem. 277:31172-31178(2002).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human BAG4.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release By similarity. Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.
Takayama S., J. Biol. Chem. 274:781-786(1999). Jiang Y., Science 283:543-546(1999). Briknarova K., J. Biol. Chem. 277:31172-31178(2002).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total BAG4protein.
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
Pathway
TNF signaling pathway
Tissue Specificity
Ubiquitous.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.