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Home / Primary Antibodies

AXIN2 Antibody (F49172)

SKU : BHA17101421

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Mfr.No.	F49172, F49172-0.08ML, F49172-0.4ML
Clonality	Polyclonal
Description	The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 816-843 from the human protein was used as the immunogen for this AXIN2 antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q9Y2T1

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the AXIN2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, FACS, ELISA
Dilution	Weste blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101421-1	F49172-0.08ML	0.08ml	$165		Add to Cart
BHA17101421-2	F49172-0.4ML	0.4ml	$379		Add to Cart

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