Aurora B is a serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. (UniProt)
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
Amino acids 89-251 were used as the immunogen for this AURKB antibody.
Isotype
Mouse IgG1
Species Reactivity
Human
Note
Optimal dilution of the AURKB antibody should be determined by the researcher.
Uniprot
Q96GD4
Format
Purified
Purity
Protein G affinity
Storage
Store the AURKB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).