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Home / Antibodies

Aurora A Antibody (R30880)

SKU : BHA17104421

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NSJ Bioreagents

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Mfr.No.	R30880
Clonality	Polyclonal
Description	Aurora kinase A, also called ARK1, AURKA, AIK , AURORA2 ,BTAK, PPP1R47, STK7, STK15, and STK6, is a mitotic centrosomal protein kinase. The main role of AURKA in tumor development is in controlling chromosome segregation during mitosis. Aurora A is a member of a family of mitotic serine/threonine kinases. Cell cycle and Northe blot analyses showed that peak expression of the protein occurs during the G2/M phase and then decreases. By fluorescence in situ hybridization, the gene is represented by 2 signals in chromosome bands 20q13.2-q13.3 and 1q41-q42. It is overexpressed in many human cancers. Ectopic overexpression of Aurora A in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Depletion of Ajuba prevented activation of AURKA at centrosomes in late G2 phase and inhibited mitotic entry. Activation of the kinase was independently sufficient to induce rapid ciliary resorption, and AURKA acted in this process through phosphorylation of HDAC6, leading to HDAC6-dependent tubulin deacetylation and destabilization of the ciliary axoneme.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the middle region of mouse AURKA (QKTEDTKKRQWTLEDFD) was used as the immunogen for this Aurora A antibody.
Isotype	IgG
Predicted Reactivity	Mouse, Rat
Reactivity	Mouse, Rat
Recombinant	No

Uniprot	P97477

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the Aurora A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Weste blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104421	R30880	100 ug	$419		Add to Cart

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