Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Host
Rabbit
Immunogen Region
A portion of the C-terminal region of the human protein was used as immunogen for this AURKC antibody.
Isotype
Rabbit Ig
Species Reactivity
Human
Note
Titration of the AURKC antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
Q9UQB9
Format
Purified
Purity
Purified
Storage
Aliquot the AURKC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.