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Home / Antibodies

ATP5A1 Antibody

SKU : BHA10558239

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA057763
Alternative Names	ATP synthase alpha chain; mitochondrial precursor; ATP5A; ATPA; EC 3.6.3.14
Categories	Primary Antibodies
Clonality	polyclonal
Description	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites By similarity.Kataoka H., Biochim. Biophys. Acta 1089:393-395(1991).Godbout R., Gene 123:195-201(1993).Akiyama S., Biochim. Biophys. Acta 1219:129-140(1994)
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ATP5A1.
Involvement In Disease	Combined oxidative phosphorylation deficiency 22 (COXPD22); Mitochondrial complex V deficiency, nuclear 4 (MC5DN4)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites By similarity. Kataoka H., Biochim. Biophys. Acta 1089:393-395(1991). Godbout R., Gene 123:195-201(1993). Akiyama S., Biochim. Biophys. Acta 1219:129-140(1994)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ATP5A1 protein.
Subcellular Location	Mitochondrion inner membrane, Cell membrane, Peripheral membrane protein, Extracellular side

Uniprot	P25705
Gene Id	498
Database Links	HGNC:823 OMIM:164360 KEGG:hsa:498 STRING:9606.ENSP00000282050 UniGene:Hs.298280
Function	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
Pathway	Myocardial Fatty Acid Metabolism Oxidative Phosphorylation
Protein Families	ATPase alpha/beta chains family
Tissue Specificity	Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord.
Weight	59751 MW

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558239	CSB-PA057763	100ul	$297		Add to Cart

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