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ATG4D Antibody

SKU : BHA10558369

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA130462
Alternative Names	APG4 autophagy 4 homolog D; APG4-D; APG4D; ATG4 autophagy related 4 homolog D (S. cerevisiae); ATG4D
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. ysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.Marino G., J. Biol. Chem. 278:3671-3678(2003).The MGC Project Team, Genome Res. 14:2121-2127(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human ATG4D.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. ysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability. Marino G., J. Biol. Chem. 278:3671-3678(2003). The MGC Project Team, Genome Res. 14:2121-2127(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ATG4Dprotein.
Subcellular Location	Cysteine protease ATG4D: Cytoplasm, SUBCELLULAR LOCATION: Cysteine protease ATG4D, mitochondrial: Cytoplasm, Mitochondrion matrix

Uniprot	Q86TL0
Gene Id	84971
Database Links	HGNC:20789 OMIM:611340 KEGG:hsa:84971 STRING:9606.ENSP00000311318 UniGene:Hs.512799
Function	Cysteine protease ATG4D
Pathway	Autophagy
Protein Families	Peptidase C54 family
Tissue Specificity	Mainly expressed in skeletal muscle and, to a lower extent, in testis.
Weight	52922

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558369	CSB-PA130462	100ul	$297		Add to Cart

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