Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production By similarity. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.Tsujimoto A., J. Virol. 65:1420-1426(1991).Karpinski B.A., Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992).Dunham I., Nature 402:489-495(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human ATF4.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production By similarity. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.
Tsujimoto A., J. Virol. 65:1420-1426(1991). Karpinski B.A., Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992). Dunham I., Nature 402:489-495(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ATF4protein.
Subcellular Location
Cytoplasm, Cell membrane, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome