This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.Yoshimura T., EMBO J. 9:2537-2542(1990).Rehfuss R.P., J. Biol. Chem. 266:18431-18434(1991).Hai T., Genes Dev. 3:2083-2090(1989).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ATF1.
Involvement In Disease
Angiomatoid fibrous histiocytoma (AFH)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Yoshimura T., EMBO J. 9:2537-2542(1990). Rehfuss R.P., J. Biol. Chem. 266:18431-18434(1991). Hai T., Genes Dev. 3:2083-2090(1989).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ATF1 protein.