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Home / Primary Antibodies

ARNTL Antibody

SKU : BHA10559066

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA555899
Alternative Names	MOP3; BMAL1c; ARNTL; TIC;
Categories	Primary Antibodies
Clonality	polyclonal
Description	ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins Lee S,et al. (2010) PLoS One.5(6):e10995. Wang J,et al. (2010) Biosystems.101(2):136-43. Jung-Hynes ,et al. (2010) J Pineal Res.49(1):60-8.
Host	Rabbit
Immunogen	Peptide sequence around aa.569~573 (S-S-S-I-L) derived from Human BMAL1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins Lee S,et al. (2010) PLoS One.5(6):e10995. Wang J,et al. (2010) Biosystems.101(2):136-43. Jung-Hynes ,et al. (2010) J Pineal Res.49(1):60-8.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total BMAL1 protein.
Subcellular Location	Nucleus, Cytoplasm, Nucleus, PML body

Uniprot	O00327
Gene Id	406
Database Links	HGNC:701 OMIM:602550 KEGG:hsa:406 STRING:9606.ENSP00000374357 UniGene:Hs.65734
Function	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components
Tissue Specificity	Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
Weight	64,136 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559066	CSB-PA555899	100ul	$297		Add to Cart

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