Armadillo repeat-containing X-linked protein 2; Protein ALEX2; ARM protein lost in epithelial cancers on chromosome X 2; ARMCX2; ALEX2
Categories
Primary Antibodies
Clonality
polyclonal
Description
This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.Nagase T., DNA Res. 5:31-39(1998).Ross M.T., Nature 434:325-337(2005).Kurochkin I.V., Biochem. Biophys. Res. Commun. 280:340-347(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ARMX2.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
Nagase T., DNA Res. 5:31-39(1998). Ross M.T., Nature 434:325-337(2005). Kurochkin I.V., Biochem. Biophys. Res. Commun. 280:340-347(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ARMX2 protein.
Subcellular Location
Mitochondrion, Mitochondrion outer membrane, Single-pass membrane protein
May regulate the dynamics and distribution of mitochondria in neural cells.
Protein Families
Eutherian X-chromosome-specific Armcx family
Tissue Specificity
Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas.
Weight
65,683 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.