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Home / Antibodies

ARHGEF12 Antibody

SKU : BHA10558646

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA111426
Alternative Names	ARHGC; ARHGEF12; Leukemia-associated RhoGEF; RHO guanine nucleotide exchange factor (GEF) 12 (LARG); Rho guanine nucleotide exchange factor 12
Categories	Primary Antibodies
Clonality	polyclonal
Description	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.Kourlas P.J., Proc. Natl. Acad. Sci. U.S.A. 97:2145-2150(2000).The MGC Project Team, Genome Res. 14:2121-2127(2004).Nagase T., DNA Res. 4:141-150(1997).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ARHGEF12.
Involvement In Disease	A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Kourlas P.J., Proc. Natl. Acad. Sci. U.S.A. 97:2145-2150(2000). The MGC Project Team, Genome Res. 14:2121-2127(2004). Nagase T., DNA Res. 4:141-150(1997).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ARHGEF12 protein.
Subcellular Location	Cytoplasm, Membrane

Uniprot	Q9NZN5
Gene Id	23365
Database Links	HGNC:14193 OMIM:604763 KEGG:hsa:23365 STRING:9606.ENSP00000380942 UniGene:Hs.24598
Function	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Pathway	Regulation of actin cytoskeleton Vascular smooth muscle contraction
Tissue Specificity	Ubiquitously expressed. Isoform 2 is found in jejunum and testis.
Weight	171,115 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558646	CSB-PA111426	100ul	$297		Add to Cart

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