May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.Nagase T., DNA Res. 4:141-150(1997).Gregory S.G., Nature 441:315-321(2006).Ruemenapp U., FEBS Lett. 459:313-318(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from N-terminal of Human ARHGEF11.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Nagase T., DNA Res. 4:141-150(1997). Gregory S.G., Nature 441:315-321(2006). Ruemenapp U., FEBS Lett. 459:313-318(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ARHGEF11 protein.
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Pathway
Vascular smooth muscle contraction
Tissue Specificity
Ubiquitously expressed.
Weight
172,244 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.