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Home / Antibodies

ARHGEF1 Antibody

SKU : BHA10558644

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA791509
Alternative Names	p115-RhoGEF; p115RhoGEF; 115 kDa guanine nucleotide exchange factor; Sub1.5;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.Farmer A., Submitted (MAY-2003).Wedegaertner P.B., J. Biol. Chem. 275:14992-14999(2000).Han D.K., Sci. Signal. 2:RA46-RA46(2009).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ARHGEF1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. Farmer A., Submitted (MAY-2003). Wedegaertner P.B., J. Biol. Chem. 275:14992-14999(2000). Han D.K., Sci. Signal. 2:RA46-RA46(2009).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ARHGEF1 protein.
Subcellular Location	Cytoplasm, Membrane

Uniprot	Q92888
Gene Id	9138
Database Links	HGNC:681 OMIM:601855 KEGG:hsa:9138 STRING:9606.ENSP00000337261 UniGene:Hs.631550
Function	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Pathway	Regulation of actin cytoskeleton Vascular smooth muscle contraction
Tissue Specificity	Ubiquitously expressed.
Weight	104,066 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558644	CSB-PA791509	100ul	$297		Add to Cart

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