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ARG1 Antibody

SKU : BHA10558230

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA182614
Alternative Names	AI; AI256583; Arg-1; ARGI1; arginase 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.Haraguchi Y., Proc. Natl. Acad. Sci. U.S.A. 84:412-415(1987).Takiguchi M., Nucleic Acids Res. 16:8789-8802(1988).Mungall A.J., Nature 425:805-811(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ARG1.
Involvement In Disease	Argininemia (ARGIN)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. Haraguchi Y., Proc. Natl. Acad. Sci. U.S.A. 84:412-415(1987). Takiguchi M., Nucleic Acids Res. 16:8789-8802(1988). Mungall A.J., Nature 425:805-811(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ARG1 protein.
Subcellular Location	Cytoplasm, Cytoplasmic granule

Uniprot	P05089
Gene Id	383
Database Links	HGNC:663 OMIM:207800 KEGG:hsa:383 STRING:9606.ENSP00000357066 UniGene:Hs.440934
Function	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.
Protein Families	Arginase family
Tissue Specificity	Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid c
Weight	25,356 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558230	CSB-PA182614	100ul	$297		Add to Cart

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