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Home / Antibodies

AR (Ab-363) Antibody

SKU : BHA10557685

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA082237
Alternative Names	ANDR; Androgen receptor; DHTR; Dihydrotestosterone receptor; NR3C4
Categories	Primary Antibodies
Clonality	polyclonal
Description	Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.Lubahn D.B., Mol. Endocrinol. 2:1265-1275(1988).Lubahn D.B., Proc. Natl. Acad. Sci. U.S.A. 86:9534-9538(1989).Govindan M.V.; Mol. Endocrinol. 4:417-427(1990).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Androgen Receptor around the phosphorylation site of tyrosine 363 (D-Y-Y(p)-N-F).
Involvement In Disease	Androgen insensitivity syndrome (AIS); Spinal and bulbar muscular atrophy X-linked 1 (SMAX1); Androgen insensitivity, partial (PAIS)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Lubahn D.B., Mol. Endocrinol. 2:1265-1275(1988). Lubahn D.B., Proc. Natl. Acad. Sci. U.S.A. 86:9534-9538(1989). Govindan M.V.; Mol. Endocrinol. 4:417-427(1990).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Androgen Receptor protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	P10275
Gene Id	367
Database Links	HGNC:644 OMIM:300068 KEGG:hsa:367 STRING:9606.ENSP00000363822 UniGene:Hs.76704
Function	Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Protein Families	Nuclear hormone receptor family, NR3 subfamily
Tissue Specificity	Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).
Weight	110kDa

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557685	CSB-PA082237	100ul	$297		Add to Cart

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