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Home / Antibodies

APG5L/ATG5 Antibody

SKU : BHA12906502

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Mfr.No.	DF6010
Alternative Names	APG 5 ; APG 5L ; APG5 ; APG5 autophagy 5 like ; APG5 like ; APG5-like ; APG5L ; Apoptosis specific protein ; Apoptosis-specific protein ; ASP ; ATG 5 ; Atg5 ; ATG5 autophagy related 5 homolog ; ATG5_HUMAN ; Autophagy protein 5 ; Autophagy related 5 ; hAPG5 ; Homolog of S Cerevisiae autophagy 5 ; OTTHUMP00000040507 ; , APG 5 ; APG 5L ; APG5 ; APG5 autophagy 5 like ; APG5 like ; APG5-like ; APG5L ; Apoptosis specific protein ; Apoptosis-specific protein ; ASP ; ATG 5 ; Atg5 ; ATG5 autophagy related 5 homolog ; ATG5_HUMAN ; Autophagy protein 5 ; Autophagy related 5 ; hAPG5 ; Homolog of S Cerevisiae autophagy 5 ; OTTHUMP00000040507 ;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents (1,2). Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer (3). The molecular machinery of autophagy was largely discovered in yeast and referred to as autophagy-related (Atg) genes. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles (4-6). This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10 (7,8).
Immunogen	A synthesized peptide derived from human ATG5., A synthesized peptide derived from human ATG5.
Molecular Weight	Observed Mol.Wt.: 32kDa. Predicted Mol.Wt.: 33kDa.
Reactivity	Human, Mouse, Rat
Specificity	ATG5 Antibody detects endogenous levels of total ATG5.
Subcellular Location	Cytoplasm. Preautophagosomal structure membrane. Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.

Uniprot

Q9H1Y0

Gene Id

9474

Sequence

10	20	30	40	50
MTDDKDVLRD	VWFGRIPTCF	TLYQDEITER	EAEPYYLLLP	RVSYLTLVTD
60	70	80	90	100
KVKKHFQKVM	RQEDISEIWF	EYEGTPLKWH	YPIGLLFDLL	ASSSALPWNI
110	120	130	140	150
TVHFKSFPEK	DLLHCPSKDA	IEAHFMSCMK	EADALKHKSQ	VINEMQKKDH
160	170	180	190	200
KQLWMGLQND	RFDQFWAINR	KLMEYPAEEN	GFRYIPFRIY	QTTTERPFIQ
210	220	230	240	250
KLFRPVAADG	QLHTLGDLLK	EVCPSAIDPE	DGEKKNQVMI	HGIEPMLETP
260	270
LQWLSEHLSY	PDNFLHISII	PQPTD

,

10	20	30	40	50
MTDDKDVLRD	VWFGRIPTCF	TLYQDEITER	EAEPYYLLLP	RVSYLTLVTD
60	70	80	90	100
KVKKHFQKVM	RQEDISEIWF	EYEGTPLKWH	YPIGLLFDLL	ASSSALPWNI
110	120	130	140	150
TVHFKSFPEK	DLLHCPSKDA	IEAHFMSCMK	EADALKHKSQ	VINEMQKKDH
160	170	180	190	200
KQLWMGLQND	RFDQFWAINR	KLMEYPAEEN	GFRYIPFRIY	QTTTERPFIQ
210	220	230	240	250
KLFRPVAADG	QLHTLGDLLK	EVCPSAIDPE	DGEKKNQVMI	HGIEPMLETP
260	270
LQWLSEHLSY	PDNFLHISII	PQPTD

Concentration	1mg/ml
Format	Liquid
Purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Applications	ELISA, IHC, WB
Dilution	WB1:500-1:2000 IHC1:50-1:200, ELISA(peptide) 1:20000-1:40000, WB1:500-1:2000 IHC1:50-1:200, ELISA(peptide) 1:20000-1:40000

Manual
MSDS
IHC Protocol.
Western Blotting Handbook.

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SKU	Supplier No.	Size	Your price	Quantity
BHA12906502	DF6010	100ul	$280		Add to Cart
BHA12906502	DF6010	200ul	$350		Add to Cart

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