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Home / Primary Antibodies / Polyclonal Antibodies

Anti-WNK1 Antibody Picoband®

SKU : BHA21000863

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Mfr.No.	PB9964, PB9964-10ug, PB9964-Biotin, PB9964-Cy3, PB9964-Dylight488, PB9964-Dylight550, PB9964-Dylight594, PB9964-FITC, PB9964-HRP, PB9964-APC, PB9964-PE, PB9964-iFluor647, PB9964-carrier-free
Alternative Names	Serine/threonine-protein kinase WNK1
Background	WNK lysine deficient protein kinase 1, also known as WNK1, is an enzyme that in humans is encoded by the WNK1 gene. The human gene is located on short arm of chromosome 12 (12p13.3). This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alteatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-WNK1 Antibody Picoband® catalog # PB9964. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride co
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human WNK1, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	250 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Serine/threonine-protein kinase WNK1;2.7.11.1;Erythrocyte 65 kDa protein;p65;Kinase deficient protein;Protein kinase lysine-deficient 1;Protein kinase with no lysine 1;hWNK1;WNK1;HSN2, KDP, KIAA0344, PRKWNK1;
Tissue Specificity	Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9H4A3
Gene Id	65125
Gene Name	WNK1
Subcellular Location	Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Rat, Human

Reference	1. "Entrez Gene: WNK1 WNK lysine deficient protein kinase 1". 2. Disse-Nicodème S, Achard JM, Desitter I, et al. (2000). "A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension.". Am. J. Hum. Genet. 67 (2): 30210. 3. Shekarabi M, Girard N, Rivière JB, et al. (July 2008). "Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II". J Clin Invest. 118 (7): 24962505.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000863-1	PB9964	100 ug	-	$370		Add to Cart
BHA21000863-2	PB9964-10ug	10 ug	Sample	$99		Add to Cart
BHA21000863-3	PB9964-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000863-4	PB9964-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000863-5	PB9964-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000863-6	PB9964-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000863-7	PB9964-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000863-8	PB9964-FITC	100 ug	FITC	$570		Add to Cart
BHA21000863-9	PB9964-HRP	100 ug	HRP	$570		Add to Cart
BHA21000863-10	PB9964-APC	100 ug	APC	$670		Add to Cart
BHA21000863-11	PB9964-PE	100 ug	PE	$670		Add to Cart
BHA21000863-12	PB9964-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000863-13	PB9964-carrier-free	100 ug	carrier-free	$370		Add to Cart

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