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Home / Primary Antibodies / Polyclonal Antibodies

Anti-VCAM1 Antibody Picoband®

SKU : BHA21001383

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Mfr.No.	A01199, A01199-10ug, A01199-Biotin, A01199-Cy3, A01199-Dylight488, A01199-Dylight550, A01199-Dylight594, A01199-FITC, A01199-HRP, A01199-APC, A01199-PE, A01199-iFluor647, A01199-carrier-free
Alternative Names	vascular cell adhesion molecule 1
Background	CD106 (cluster of differentiation 106) also known as vascular cell adhesion molecule 1 (VCAM-1), is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. This gene is mapped to chromosome 1 by Southe analysis of somatic cell hybrids. VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide ofVCAM1. Among the lung metastasis signature genes identified, several, includingVCAM1, were functionally validated.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-VCAM1 Antibody Picoband® catalog # A01199. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may p
Host	Rabbit
Immunogen Region	E. coli-derived mouse VCAM1 recombinant protein (Position: F25-L270).
Isotype	Rabbit IgG
Molecular Weight	110 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD106; Vcam1; Vcam-1;
Tissue Specificity	Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Vcam1: P29533
Gene Id	22329
Gene Name	Vcam1
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA (Cap), 1-5ug/ml<br>

Reference	1. Cybulsky, M., Fries, J. W., Williams, A. J., Sultan, P., Eddy, R. L., Byers, M. G., Shows, T. B., Gimbrone, M. A., Jr., Collins, T. The human VCAM1 gene is assigned to chromosome 1p31-p32. (Abstract)Cytogenet. Cell Genet. 58: 1852, 1991.<br /><br />2. Kumar, A. G., Dai, X. Y., Kozak, C. A., Mims, M. P., Gotto, A. M., Ballantyne, C. M. Murine VCAM-1: molecular cloning, mapping, and analysis of a truncated form. J. Immun. 153: 4088-4098, 1994.<br /><br />3. Taylor, J. G., VI, Tang, D. C., Savage, S. A., Leitman, S. F., Heller, S. I., Serjeant, G. R., Rodgers, G. P., Chanock, S. J. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. Blood 100: 4303-4309, 2002.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001383-1	A01199	100 ug	-	$370		Add to Cart
BHA21001383-2	A01199-10ug	10 ug	Sample	$99		Add to Cart
BHA21001383-3	A01199-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001383-4	A01199-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001383-5	A01199-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001383-6	A01199-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001383-7	A01199-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001383-8	A01199-FITC	100 ug	FITC	$570		Add to Cart
BHA21001383-9	A01199-HRP	100 ug	HRP	$570		Add to Cart
BHA21001383-10	A01199-APC	100 ug	APC	$670		Add to Cart
BHA21001383-11	A01199-PE	100 ug	PE	$670		Add to Cart
BHA21001383-12	A01199-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001383-13	A01199-carrier-free	100 ug	carrier-free	$370		Add to Cart

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