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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Tyrosine-protein kinase Tec Tec Antibody Picoband®

SKU : BHA21007227

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Mfr.No.	PA2000, PA2000-10ug, PA2000-Biotin, PA2000-Cy3, PA2000-Dylight488, PA2000-Dylight550, PA2000-Dylight594, PA2000-FITC, PA2000-HRP, PA2000-APC, PA2000-PE, PA2000-iFluor647, PA2000-carrier-free
Alternative Names	Tyrosine-protein kinase Tec
Background	TEC (TEC Protein Tyrosine Kinase), is an enzyme that in humans is encoded by the TEC gene. The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. By fluorescence in situ hybridization, Sato et al. (1994) mapped the gene to 4p12, the same location reported for TXK. Mouse Tec is a non-receptor type protein-tyrosine kinase that is highly expressed in many hematopoietic cell lines. Hantschel et al. (2007) identified TEC kinase and BTK kinase as major binders of the tyrosine kinase inhibitor dasatinib, which is used for treatment of BCR/ABL-positive CML.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Tyrosine-protein kinase Tec Tec Antibody catalog # PA2000. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adap
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Tec, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	58-60 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tyrosine-protein kinase Tec;2.7.10.2;TEC;PSCTK4;
Tissue Specificity	Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg Thimerosal, 0.01mg NaN3.

Uniprot	P42680
Gene Name	TEC
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat<br>

Reference	1. Hantschel, O., Rix, U., Schmidt, U., Burckstummer, T., Kneidinger, M., Schutze, G., Colinge, J., Bennett, K. L., Ellmeier, W., Valent, P., Superti-Furga, G. The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc. Nat. Acad. Sci. 104: 13283-13288, 2007.<br /><br />2. Sato, K., Mano, H., Ariyama, T., Inazawa, J., Yazaki, Y., Hirai, H. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. Leukemia 8: 1663-1672, 1994.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007227-1	PA2000	-	100 ug	$370		Add to Cart
BHA21007227-2	PA2000-10ug	Sample	10 ug	$99		Add to Cart
BHA21007227-3	PA2000-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007227-4	PA2000-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007227-5	PA2000-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007227-6	PA2000-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007227-7	PA2000-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007227-8	PA2000-FITC	FITC	100 ug	$570		Add to Cart
BHA21007227-9	PA2000-HRP	HRP	100 ug	$570		Add to Cart
BHA21007227-10	PA2000-APC	APC	100 ug	$670		Add to Cart
BHA21007227-11	PA2000-PE	PE	100 ug	$670		Add to Cart
BHA21007227-12	PA2000-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007227-13	PA2000-carrier-free	carrier-free	100 ug	$370		Add to Cart

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