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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Tuberin/TSC2 Antibody Picoband®

SKU : BHA21000027

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Mfr.No.	PB9121, PB9121-10ug, PB9121-Biotin, PB9121-Cy3, PB9121-Dylight488, PB9121-Dylight550, PB9121-Dylight594, PB9121-FITC, PB9121-HRP, PB9121-APC, PB9121-PE, PB9121-iFluor647, PB9121-carrier-free
Alternative Names	Tuberin
Background	Tuberous sclerosis 2 protein, also known as TSC2 or Tuberin is a protein that is in humans. The chromosomal location of this gene is 16p13.3. Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. This gene involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. It stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Tuberin/TSC2 Antibody Picoband® catalog # PB9121. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a activator of the prot
Host	Rabbit
Immunogen Region	E.coli-derived human Tuberin recombinant protein (Position: H1611-V1807). Human Tuberin shares 94% and 90% amino acid (aa) sequences identity with mouse and rat Tuberin, respectively.
Isotype	Rabbit IgG
Molecular Weight	201 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tuberin;Tuberous sclerosis 2 protein;TSC2;TSC4;
Tissue Specificity	Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P49815
Gene Id	7249
Gene Name	TSC2
Sequence	Contains 1 Rap-GAP domain.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Chu-Shore, C. J., Major, P., Montenegro, M., Thiele, E. Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex. Neurology 72: 1165-1169, 2009. 2. Jansen, F. E., Braams, O., Vincken, K. L., Algra, A., Anbeek, P., Jennekens-Schinkel, A., Halley, D., Zonnenberg, B. A., van den Ouweland, A., van Huffelen, A. C., van Nieuwenhuizen, O., Nellist, M. Overlapping neurologic and cognitive phenotypes in patients with TSC1 or TSC2 mutations. Neurology 70: 908-915, 2008.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000027-1	PB9121	100 ug	-	$370		Add to Cart
BHA21000027-3	PB9121-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000027-4	PB9121-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000027-5	PB9121-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000027-6	PB9121-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000027-7	PB9121-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000027-8	PB9121-FITC	100 ug	FITC	$570		Add to Cart
BHA21000027-9	PB9121-HRP	100 ug	HRP	$570		Add to Cart
BHA21000027-10	PB9121-APC	100 ug	APC	$670		Add to Cart
BHA21000027-11	PB9121-PE	100 ug	PE	$670		Add to Cart
BHA21000027-12	PB9121-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000027-13	PB9121-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000027-2	PB9121-10ug	10 ug	Sample	$99		Add to Cart

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