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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TTC11/FIS1 Antibody Picoband®

SKU : BHA21004191

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Mfr.No.	A01932-3, A01932-3-10ug, A01932-3-Biotin, A01932-3-Cy3, A01932-3-Dylight488, A01932-3-Dylight550, A01932-3-Dylight594, A01932-3-FITC, A01932-3-HRP, A01932-3-APC, A01932-3-PE, A01932-3-iFluor647, A01932-3-carrier-free
Alternative Names	fission, mitochondrial 1
Background	Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7. It is mapped to 7q22.1. The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission. Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology, the cell cycle, and apoptosis. By extension, the protein is involved in associated diseases, including neurodegenerative diseases and cancers.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TTC11/FIS1 Antibody Picoband® catalog # A01932-3. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fissi
Host	Rabbit
Immunogen Region	E.coli-derived human TTC11/FIS1 recombinant protein (Position: E18-S152).
Isotype	Rabbit IgG
Molecular Weight	17 kDa
Reactivity	Human, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Mitochondrial fission 1 protein; FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11; FIS1; TTC11; CGI-135
Tissue Specificity	Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9Y3D6
Gene Id	51024
Gene Name	FIS1
Subcellular Location	Mitochondrion outer membrane. Single-pass membrane protein. Peroxisome membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Rat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Dohm, J. A., Lee, S. J., Hardwick, J. M., Hill, R. B., Gittis, A. G. Cytosolic domain of the human mitochondrial fission protein Fis1 adopts a TPR fold. Proteins 54: 153-156, 2004.<br /><br />2. Frieden, M., James, D., Castelbou, C., Danckaert, A., Martinou, J.-C., Demaurex, N. Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1. J. Biol. Chem. 279: 22704-22714, 2004. <br /><br />3. James, D. I., Parone, P. A., Mattenberger, Y., Martinou, J.-C. hFis1, a novel component of the mammalian mitochondrial fission machinery. J. Biol. Chem. 278: 36373-36379, 2003. Note: Erratum: J. Biol. Chem. 279: 36166 only, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004191-1	A01932-3	-	100 ug	$370		Add to Cart
BHA21004191-2	A01932-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004191-3	A01932-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004191-4	A01932-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004191-5	A01932-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004191-6	A01932-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004191-7	A01932-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004191-8	A01932-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004191-9	A01932-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004191-10	A01932-3-APC	APC	100 ug	$670		Add to Cart
BHA21004191-11	A01932-3-PE	PE	100 ug	$670		Add to Cart
BHA21004191-12	A01932-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004191-13	A01932-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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