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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TRPV5 Antibody Picoband®

SKU : BHA21000412

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Mfr.No.	PB9518, PB9518-10ug, PB9518-Biotin, PB9518-Cy3, PB9518-Dylight488, PB9518-Dylight550, PB9518-Dylight594, PB9518-FITC, PB9518-HRP, PB9518-APC, PB9518-PE, PB9518-iFluor647, PB9518-carrier-free
Alternative Names	Transient receptor potential cation channel subfamily V member 5
Background	Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene. This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. And this protein forms homotetramers or heterotetramers and is activated by a low inteal calcium level. In addition, TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequential hyperparathyroidism, and bone loss.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TRPV5 Antibody Picoband® catalog # PB9518. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Constitutively active calcium selective cation channel thought to be involved in Ca (2+) reabsorption in kidney and intestine. The channel is activated by low inteal calcium level and the current exhibits an inward rectification. A Ca (2+)- dependent fe
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TRPV5, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	83 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Transient receptor potential cation channel subfamily V member 5;TrpV5;Calcium transport protein 2;CaT2;Epithelial calcium channel 1;ECaC;ECaC1;Osm-9-like TRP channel 3;OTRPC3;TRPV5;ECAC1;
Tissue Specificity	Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9NQA5
Gene Id	56302
Gene Name	TRPV5
Sequence	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.
Subcellular Location	Apical cell membrane ; Multi-pass membrane protein . Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "Inteational Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels".Pharmacol. Rev. 57 (4): 42750. 2. Müller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI et al. (Nov 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics 67 (1): 4853. 3. Müller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochem. Biophys. Res. Commun. 275 (1): 4752.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000412-1	PB9518	100 ug	-	$370		Add to Cart
BHA21000412-2	PB9518-10ug	10 ug	Sample	$99		Add to Cart
BHA21000412-3	PB9518-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000412-4	PB9518-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000412-5	PB9518-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000412-6	PB9518-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000412-7	PB9518-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000412-8	PB9518-FITC	100 ug	FITC	$570		Add to Cart
BHA21000412-9	PB9518-HRP	100 ug	HRP	$570		Add to Cart
BHA21000412-10	PB9518-APC	100 ug	APC	$670		Add to Cart
BHA21000412-11	PB9518-PE	100 ug	PE	$670		Add to Cart
BHA21000412-12	PB9518-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000412-13	PB9518-carrier-free	100 ug	carrier-free	$370		Add to Cart

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