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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TrkA/NTRK1 Antibody Picoband®

SKU : BHA21007351

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Mfr.No.	PA2149-2, PA2149-2-10ug, PA2149-2-Biotin, PA2149-2-Cy3, PA2149-2-Dylight488, PA2149-2-Dylight550, PA2149-2-Dylight594, PA2149-2-FITC, PA2149-2-HRP, PA2149-2-APC, PA2149-2-PE, PA2149-2-iFluor647, PA2149-2-carrier-free
Alternative Names	High affinity nerve growth factor receptor
Background	Neurotrophic tyrosine kinase receptor type 1, also called Trk-A, is a protein that in humans is encoded by the NTRK1 gene. The NTKR1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors whose ligands include neurotrophins. This gene is mapped to 1q23.1. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TrkA/NTRK1 Antibody catalog # PA2149-2. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF whic
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of mouse TrkA, different from the related rat sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	41 kDa
Reactivity	Rat, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	High affinity nerve growth factor receptor;2.7.10.1;Neurotrophic tyrosine kinase receptor type 1;Ntrk1;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q3UFB7
Gene Name	NTRK1
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). Intealized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br>

Reference	1. Bibel, M., Barde, Y.-A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14: 2919-2937, 2000.<br /><br />2. Chuang, H., Prescott, E. D., Kong, H., Shields, S., Jordt, S.-E., Basbaum, A. I., Chao, M. V., Julius, D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411: 957-962, 2001.<br /><br />3. Kuruvilla, R., Zweifel, L. S., Glebova, N. O., Lonze, B. E., Valdez, G., Ye, H., Ginty, D. D.A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 118: 243-255, 2004.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007351-1	PA2149-2	-	100 ug	$370		Add to Cart
BHA21007351-2	PA2149-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21007351-3	PA2149-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007351-4	PA2149-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007351-5	PA2149-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007351-6	PA2149-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007351-7	PA2149-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007351-8	PA2149-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21007351-9	PA2149-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21007351-10	PA2149-2-APC	APC	100 ug	$670		Add to Cart
BHA21007351-11	PA2149-2-PE	PE	100 ug	$670		Add to Cart
BHA21007351-12	PA2149-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007351-13	PA2149-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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