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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TRAP/CD40L/CD40LG Antibody Picoband®

SKU : BHA21003277

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Mfr.No.	A01114-4, A01114-4-10ug, A01114-4-Biotin, A01114-4-Cy3, A01114-4-Dylight488, A01114-4-Dylight550, A01114-4-Dylight594, A01114-4-FITC, A01114-4-HRP, A01114-4-APC, A01114-4-PE, A01114-4-iFluor647, A01114-4-carrier-free
Alternative Names	CD40 ligand
Background	CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells.CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TRAP/CD40L/CD40LG Antibody Picoband® catalog # A01114-4. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 c
Host	Rabbit
Immunogen Region	E.coli-derived human TRAP/CD40L/CD40LG recombinant protein (Position: E76-H249).
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5; CD154; CD40LG; CD40L; TNFSF5; TRAP
Tissue Specificity	Specifically expressed on activated CD4+ T-lymphocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	P29965
Gene Id	959
Gene Name	CD40LG
Subcellular Location	Cell membrane. Single-pass type II membrane protein. Cell surface. Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human, Rat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Allen,R.C.;Armitage,R.J.;Conley,M.E.;Rosenblatt,H.;Jenkins,N.A.;Copeland,N.G.;Bedell,M.A.;Edelhoff,S.;Disteche,C.M.;Simoneaux,D.K.;Fanslow,W.C.; Belmont,J.;Spriggs,M.K.:CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259: 990-993, 1993.<br /><br />2. Cipollone,F.;Ferri,C.;Desideri,G.;Paloscia,L.;Materazzo,G.;Mascellanti,M.;Fazia,M.;Iezzi,A.;Cuccurullo,C.;Pini,B.;Bucci,M.;Santucci,A.;Cuccurullo,F.; Mezzetti,A.:Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty. Circulation 108: 2776-2782, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003277-1	A01114-4	-	100 ug	$370		Add to Cart
BHA21003277-2	A01114-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21003277-3	A01114-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003277-4	A01114-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003277-5	A01114-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003277-6	A01114-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003277-7	A01114-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003277-8	A01114-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21003277-9	A01114-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21003277-10	A01114-4-APC	APC	100 ug	$670		Add to Cart
BHA21003277-11	A01114-4-PE	PE	100 ug	$670		Add to Cart
BHA21003277-12	A01114-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003277-13	A01114-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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