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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TRAF2 Antibody Picoband®

SKU : BHA21007232

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Mfr.No.	PA2007, PA2007-10ug, PA2007-Biotin, PA2007-Cy3, PA2007-Dylight488, PA2007-Dylight550, PA2007-Dylight594, PA2007-FITC, PA2007-HRP, PA2007-APC, PA2007-PE, PA2007-iFluor647, PA2007-carrier-free
Alternative Names	TNF receptor-associated factor 2
Background	TRAF2 (TNF Receptor-Associated Factor 2), also called TRAP, is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF2 is a common signal transducer for TNFR2 and CD40 that mediates activation of NF-kappa-B. Rothe et al. (1996) identified ITRAF, which binds to TRAF1, TRAF2, and TRAF3, and that when overexpressed inhibits TRAF2-mediated NF-kappa-B activation. They proposed that ITRAF is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Kanamori et al. (2002) found that mouse Traf2 interacted ly with T2bp, and they presented evidence that T2BP is involved in TNF-mediated signaling by its interaction with TRAF2.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TRAF2 Antibody catalog # PA2007. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ub
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human TRAF2, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	TNF receptor-associated factor 2;6.3.2.-;E3 ubiquitin-protein ligase TRAF2;Tumor necrosis factor type 2 receptor-associated protein 3;TRAF2;TRAP3;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q12933
Gene Name	TRAF2
Sequence	Belongs to the TNF receptor-associated factor family. A subfamily.
Subcellular Location	Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, -<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., Watanabe, T. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NF-kappa-B activation. J. Biol. Chem. 272: 2042-2045, 1997.<br /><br />2. Kanamori, M., Suzuki, H., Saito, R., Muramatsu, M., Hayashizaki, Y. T2BP, a novel TRAF2 binding protein, can activate NF-kappa-B and AP-1 without TNF stimulation. Biochem. Biophys. Res. Commun. 290: 1108-1113, 2002.<br /><br />3. Rothe, M., Xiong, J., Shu, H.-B., Williamson, K., Goddard, A., Goeddel, D. V. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Nat. Acad. Sci. 93: 8241-8246, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007232-1	PA2007	-	100 ug	$370		Add to Cart
BHA21007232-2	PA2007-10ug	Sample	10 ug	$99		Add to Cart
BHA21007232-3	PA2007-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007232-4	PA2007-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007232-5	PA2007-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007232-6	PA2007-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007232-7	PA2007-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007232-8	PA2007-FITC	FITC	100 ug	$570		Add to Cart
BHA21007232-9	PA2007-HRP	HRP	100 ug	$570		Add to Cart
BHA21007232-10	PA2007-APC	APC	100 ug	$670		Add to Cart
BHA21007232-11	PA2007-PE	PE	100 ug	$670		Add to Cart
BHA21007232-12	PA2007-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007232-13	PA2007-carrier-free	carrier-free	100 ug	$370		Add to Cart

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