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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TORC1/CRTC1 Antibody Picoband®

SKU : BHA21002332

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Mfr.No.	A01951-2, A01951-2-10ug, A01951-2-Biotin, A01951-2-Cy3, A01951-2-Dylight488, A01951-2-Dylight550, A01951-2-Dylight594, A01951-2-FITC, A01951-2-HRP, A01951-2-APC, A01951-2-PE, A01951-2-iFluor647, A01951-2-carrier-free
Alternative Names	CREB regulated transcription coactivator 1
Background	CRTC1 (CREB-Regulated Transcription Coactivator 1), also known as MECT1, TORC1 or KIAA0616, is a protein that in humans is encoded by the CRTC1 gene. By sequence analysis, Tonon et al. (2003) mapped the CRTC1 gene to chromosome 19p13. Kovacs et al. (2007) found that Torc1 was expressed in adult mouse brain and cultured neurons, and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways. Mair et al. (2011) demonstrated that CRTC1 is a AMPK target, and interacts with the CREB homolog-1 (CRH1) transcription factor in vivo. The prolongevity effects of activating AMPK or deactivating calcineurin decrease CRTC1 and CRH1 activity and induce transcriptional responses similar to those of CRH1-null worms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TORC1/CRTC1 Antibody Picoband® catalog # A01951-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently o
Host	Rabbit
Immunogen Region	E.coli-derived human TORC1/CRTC1 recombinant protein (Position: E30-E568).
Isotype	Rabbit IgG
Molecular Weight	78 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1; CRTC1; KIAA0616
Tissue Specificity	Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q6UUV9
Gene Id	23373
Gene Name	CRTC1
Subcellular Location	Nucleus. Cytoplasm. Membrane. Peripheral membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IHC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Kovacs, K. A. Steullet, P., Steinmann, M., Do, K. Q., Magistretti, P. J., Halfon, O., Cardinaux, J.-R. TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc. Nat. Acad. Sci. 104: 4700-4705, 2007.<br /><br />2. Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., Dillin, A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470: 404-408, 2011.<br /><br />3. Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A. B., Komiya, T., O'Neil, K., Stover, K., El-Naggar, A., Griffin, J. D., Kirsch, I. R., Kaye, F. J. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nature Genet. 33: 208-213, 2003. Note: Erratum: Nature Genet. 33: 430 only, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002332-1	A01951-2	-	100 ug	$370		Add to Cart
BHA21002332-2	A01951-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002332-3	A01951-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002332-4	A01951-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002332-5	A01951-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002332-6	A01951-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002332-7	A01951-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002332-8	A01951-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002332-9	A01951-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002332-10	A01951-2-APC	APC	100 ug	$670		Add to Cart
BHA21002332-11	A01951-2-PE	PE	100 ug	$670		Add to Cart
BHA21002332-12	A01951-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002332-13	A01951-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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