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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Toll-like receptor 8 TLR8 Antibody Picoband®

SKU : BHA21007016

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Mfr.No.	PA1734, PA1734-10ug, PA1734-Biotin, PA1734-Cy3, PA1734-Dylight488, PA1734-Dylight550, PA1734-Dylight594, PA1734-FITC, PA1734-HRP, PA1734-APC, PA1734-PE, PA1734-iFluor647, PA1734-carrier-free
Alternative Names	toll-like receptor 8
Background	TLR8 (Toll-like receptor 8) is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288). The TLR8 gene is mapped to Xp22.3-p22.2 by Chuang and Ulevitch (2000) and Du et al. (2000). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular pattes (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different pattes of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. TLR8 recognises G-rich oligonucleotides.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Toll-like receptor 8 TLR8 Antibody catalog # PA1734. Tested in WB applications. This antibody reacts with Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular pattes specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-st
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of rat TLR8, different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Protein Tlr8 ;Toll-like receptor 8 ;Tlr8 ;
Tissue Specificity	Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	A5H300
Gene Name	TLR8
Sequence	Belongs to the Toll-like receptor family.
Subcellular Location	Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Rat<br>

Reference	1. Chuang, T.-H., Ulevitch, R. J.Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.Europ. Cytokine Netw. 11: 372-378, 2000. <br /><br />2. Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., Liu, Y.-J.Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens.J. Exp. Med. 194: 863-869, 2001.<br /><br />3. Peng, G., Guo, Z., Kiniwa, Y., Voo, K., Peng, W., Fu, T., Wang, D. Y., Li, Y., Wang, H. Y., Wang, R.-F.Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.Science 309: 1380-1384, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007016-1	PA1734	-	100 ug	$370		Add to Cart
BHA21007016-2	PA1734-10ug	Sample	10 ug	$99		Add to Cart
BHA21007016-3	PA1734-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007016-4	PA1734-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007016-5	PA1734-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007016-6	PA1734-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007016-7	PA1734-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007016-8	PA1734-FITC	FITC	100 ug	$570		Add to Cart
BHA21007016-9	PA1734-HRP	HRP	100 ug	$570		Add to Cart
BHA21007016-10	PA1734-APC	APC	100 ug	$670		Add to Cart
BHA21007016-11	PA1734-PE	PE	100 ug	$670		Add to Cart
BHA21007016-12	PA1734-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007016-13	PA1734-carrier-free	carrier-free	100 ug	$370		Add to Cart

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