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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Toll-like receptor 7 TLR7 Antibody Picoband®

SKU : BHA21007015

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Mfr.No.	PA1733, PA1733-10ug, PA1733-Biotin, PA1733-Cy3, PA1733-Dylight488, PA1733-Dylight550, PA1733-Dylight594, PA1733-FITC, PA1733-HRP, PA1733-APC, PA1733-PE, PA1733-iFluor647, PA1733-carrier-free
Alternative Names	Toll-like receptor 7
Background	TLR7 (Toll-like receptor 7) is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular pattes (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different pattes of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are intealised by macrophages.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Toll-like receptor 7 TLR7 Antibody catalog # PA1733. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular pattes specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-st
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TLR7, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Toll-like receptor 7;TLR7;UNQ248/PRO285;
Tissue Specificity	Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9NYK1
Gene Name	TLR7
Sequence	Belongs to the Toll-like receptor family.
Subcellular Location	Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat <br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., Reis e Sousa, C.Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.Science 303: 1529-1531, 2004.<br /><br />2. Hayashi, T., Gray, C. S., Chan, M., Tawatao, R., Ronacher, L., McGargill, M. A., Datta, S. K., Carson, D. A., Corr, M.Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.<br /><br />3. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S.Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.Nature Immun. 3: 196-200, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007015-1	PA1733	-	100 ug	$370		Add to Cart
BHA21007015-2	PA1733-10ug	Sample	10 ug	$99		Add to Cart
BHA21007015-3	PA1733-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007015-4	PA1733-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007015-5	PA1733-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007015-6	PA1733-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007015-7	PA1733-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007015-8	PA1733-FITC	FITC	100 ug	$570		Add to Cart
BHA21007015-9	PA1733-HRP	HRP	100 ug	$570		Add to Cart
BHA21007015-10	PA1733-APC	APC	100 ug	$670		Add to Cart
BHA21007015-11	PA1733-PE	PE	100 ug	$670		Add to Cart
BHA21007015-12	PA1733-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007015-13	PA1733-carrier-free	carrier-free	100 ug	$370		Add to Cart

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