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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TFEB Antibody Picoband®

SKU : BHA21004418

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Mfr.No.	A00662-4, A00662-4-10ug, A00662-4-Biotin, A00662-4-Cy3, A00662-4-Dylight488, A00662-4-Dylight550, A00662-4-Dylight594, A00662-4-FITC, A00662-4-HRP, A00662-4-APC, A00662-4-PE, A00662-4-iFluor647, A00662-4-carrier-free
Alternative Names	killer cell lectin like receptor K1
Background	Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis. It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm to the nucleus, resulting in the activation of its target genes. TFEB overexpression in cultured cells induces lysosomal biogenesis, exocytosis and autophagy. Viral-mediated TFEB overexpression in cellular and mouse models of lysosomal storage disorders and in common neurodegenerative diseases such as Huntington, Parkinson and Alzheimer diseases, resulted in intracellular clearance of accumulating molecules and rescue of disease phenotypes. TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease. TFEB overexpression has been found in patients with renal cell carcinoma and pancreatic cancer and was shown to promote tumorogenesis via induction of varius oncogenic signals.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TFEB Antibody Picoband® catalog # A00662-4. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costim
Host	Rabbit
Immunogen Region	E.coli-derived human TFEB recombinant protein (Position: A214-H326).
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD314; KLRK1; D12S2489E; NKG2D
Tissue Specificity	Expressed in natural killer (NK) cells, CD8 (+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P19484
Gene Id	7942
Gene Name	TFEB
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.25 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10^6 cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Argani, P., Hawkins, A., Griffin, C. A., Goldstein, J. D., Haas, M., Beckwith, J. B., Mankinen, C. B., Perlman, E. J. A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation. Am. J. Path. 158: 2089-2096, 2001.<br /><br />2. Carr, C. S., Sharp, P. A. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Molec. Cell. Biol. 10: 4384-4388, 1990.<br /><br />3. Davis, I. J., Hsi, B.-L., Arroyo, J. D., Vargas, S. O., Yeh, Y. A., Motyckova, G., Valencia, P., Perez-Atayde, A. R., Argani, P., Ladanyi, M., Fletcher, J. A., Fisher, D. E. Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc. Nat. Acad. Sci. 100: 6051-6056, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004418-1	A00662-4	-	100 ug	$370		Add to Cart
BHA21004418-2	A00662-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21004418-3	A00662-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004418-4	A00662-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004418-5	A00662-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004418-6	A00662-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004418-7	A00662-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004418-8	A00662-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21004418-9	A00662-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21004418-10	A00662-4-APC	APC	100 ug	$670		Add to Cart
BHA21004418-11	A00662-4-PE	PE	100 ug	$670		Add to Cart
BHA21004418-12	A00662-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004418-13	A00662-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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