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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Survivin/BIRC5 Antibody Picoband®

SKU : BHA21000169

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Mfr.No.	RP1052, RP1052-10ug, RP1052-Biotin, RP1052-Cy3, RP1052-Dylight488, RP1052-Dylight550, RP1052-Dylight594, RP1052-FITC, RP1052-HRP, RP1052-APC, RP1052-PE, RP1052-iFluor647, RP1052-carrier-free
Alternative Names	Baculoviral IAP repeat-containing protein 5
Background	Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that in humans encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin gene contains 4 exons. This gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions as inhibitor caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Survivin/BIRC5 Antibody catalog # RP1052. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as
Host	Rabbit
Immunogen Region	E.coli-derived mouse Survivin recombinant protein (Position: M1-A140). Mouse Survivin shares 85% and 91% amino acid (aa) sequence identity with human and rat Survivin, respectively.
Isotype	Rabbit IgG
Molecular Weight	16 kDa
Reactivity	Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Baculoviral IAP repeat-containing protein 5;Apoptosis inhibitor 4;Apoptosis inhibitor survivin;TIAP;Birc5;Api4, Iap4;
Tissue Specificity	Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	O70201
Gene Id	11799
Gene Name	BIRC5
Sequence	Belongs to the IAP family.
Subcellular Location	Cytoplasm . Nucleus . Chromosome. Chromosome, centromere . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Midbody . Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 s its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Mous Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Mouse

Reference	1. Ambrosini, G., Adida, C., Altieri, D. C.A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.Nature Med. 3: 917-921, 1997. 2. Chantalat, L., Skoufias, D. A., Kleman, J.-P., Jung, B., Dideberg, O., Margolis, R. L.Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.Molec. Cell 6: 183-189, 2000.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000169-1	RP1052	100 ug	-	$370		Add to Cart
BHA21000169-2	RP1052-10ug	10 ug	Sample	$99		Add to Cart
BHA21000169-3	RP1052-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000169-4	RP1052-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000169-5	RP1052-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000169-6	RP1052-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000169-7	RP1052-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000169-8	RP1052-FITC	100 ug	FITC	$570		Add to Cart
BHA21000169-9	RP1052-HRP	100 ug	HRP	$570		Add to Cart
BHA21000169-10	RP1052-APC	100 ug	APC	$670		Add to Cart
BHA21000169-11	RP1052-PE	100 ug	PE	$670		Add to Cart
BHA21000169-12	RP1052-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000169-13	RP1052-carrier-free	100 ug	carrier-free	$370		Add to Cart

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