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Home / Primary Antibodies / Polyclonal Antibodies

Anti-survivin/BIRC5 Antibody Picoband®

SKU : BHA21006820

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Mfr.No.	PA1474, PA1474-10ug, PA1474-Biotin, PA1474-Cy3, PA1474-Dylight488, PA1474-Dylight550, PA1474-Dylight594, PA1474-FITC, PA1474-HRP, PA1474-APC, PA1474-PE, PA1474-iFluor647, PA1474-carrier-free
Alternative Names	Baculoviral IAP repeat-containing protein 5
Background	Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin gene contains 4 exons. The survivin gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-survivin/BIRC5 Antibody catalog # PA1474. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human survivin.
Isotype	Rabbit IgG
Molecular Weight	38 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Baculoviral IAP repeat-containing protein 5;Apoptosis inhibitor 4;Apoptosis inhibitor survivin;BIRC5;API4, IAP4;
Tissue Specificity	Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	O15392
Gene Name	BIRC5
Sequence	Belongs to the IAP family.
Subcellular Location	Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 s its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Ambrosini, G., Adida, C., Altieri, D. C.A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.Nature Med. 3: 917-921, 1997.<br /><br />2. Chantalat, L., Skoufias, D. A., Kleman, J.-P., Jung, B., Dideberg, O., Margolis, R. L.Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.Molec. Cell 6: 183-189, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006820-1	PA1474	-	100 ug	$370		Add to Cart
BHA21006820-2	PA1474-10ug	Sample	10 ug	$99		Add to Cart
BHA21006820-3	PA1474-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006820-4	PA1474-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006820-5	PA1474-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006820-6	PA1474-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006820-7	PA1474-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006820-8	PA1474-FITC	FITC	100 ug	$570		Add to Cart
BHA21006820-9	PA1474-HRP	HRP	100 ug	$570		Add to Cart
BHA21006820-10	PA1474-APC	APC	100 ug	$670		Add to Cart
BHA21006820-11	PA1474-PE	PE	100 ug	$670		Add to Cart
BHA21006820-12	PA1474-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006820-13	PA1474-carrier-free	carrier-free	100 ug	$370		Add to Cart

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