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Home / Primary Antibodies / Polyclonal Antibodies

Anti-STXBP2 Antibody Picoband®

SKU : BHA21000720

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Mfr.No.	PB9820, PB9820-10ug, PB9820-Biotin, PB9820-Cy3, PB9820-Dylight488, PB9820-Dylight550, PB9820-Dylight594, PB9820-FITC, PB9820-HRP, PB9820-APC, PB9820-PE, PB9820-iFluor647, PB9820-carrier-free
Alternative Names	Syntaxin-binding protein 2
Background	Syntaxin-binding protein 2, also known as UNC18B, is a protein that in humans is encoded by the STXBP2 gene. The STXBP2 gene is mapped to human chromosome 19p13.3-p13.2 and to the proximal arm of mouse chromosome 8. And this gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Additionally, UNC18B is expressed predominantly as a 2.4-kb message in placenta, lung, liver, kidney, and pancreas, as well as in peripheral blood lymphocytes. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alteatively spliced transcript variants encoding different isoforms have been noted for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-STXBP2 Antibody Picoband® catalog # PB9820. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human STXBP2, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	66 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Syntaxin-binding protein 2;Protein unc-18 homolog 2;Unc18-2;Protein unc-18 homolog B;Unc-18B;STXBP2;UNC18B;
Tissue Specificity	Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q15833
Gene Id	6813
Gene Name	STXBP2
Subcellular Location	Cytoplasm, cytosol . Membrane; Peripheral membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: STXBP2 syntaxin binding protein 2". 2. Cetica, V., Santoro, A., Gilmour, K. C., Sieni, E., Beutel, K., Pende, D., Marcenaro, S., Koch, F., Grieve, S., Wheeler, R., Zhao, F., zur Stadt, U., Griffiths, G. M., Arico, M. STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5. J. Med. Genet. 47: 595-600, 2010. 3. Ziegler, S.F., Mortrud, M. T., Swartz, A. R., Baker, E., Sutherland, G. R., Burmeister, M., Mulligan, J. T. Molecular characterization of a nonneuronal human UNC18 homolog. Genomics 37: 19-23, 1996.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000720-1	PB9820	100 ug	-	$370		Add to Cart
BHA21000720-2	PB9820-10ug	10 ug	Sample	$99		Add to Cart
BHA21000720-3	PB9820-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000720-4	PB9820-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000720-5	PB9820-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000720-6	PB9820-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000720-7	PB9820-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000720-8	PB9820-FITC	100 ug	FITC	$570		Add to Cart
BHA21000720-9	PB9820-HRP	100 ug	HRP	$570		Add to Cart
BHA21000720-10	PB9820-APC	100 ug	APC	$670		Add to Cart
BHA21000720-11	PB9820-PE	100 ug	PE	$670		Add to Cart
BHA21000720-12	PB9820-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000720-13	PB9820-carrier-free	100 ug	carrier-free	$370		Add to Cart

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