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Home / Primary Antibodies / Polyclonal Antibodies

Anti-splicing factor 1/SF1 Antibody Picoband®

SKU : BHA21007122

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Mfr.No.	PA1864, PA1864-10ug, PA1864-Biotin, PA1864-Cy3, PA1864-Dylight488, PA1864-Dylight550, PA1864-Dylight594, PA1864-FITC, PA1864-HRP, PA1864-APC, PA1864-PE, PA1864-iFluor647, PA1864-carrier-free
Alternative Names	Splicing factor 1
Background	Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene. This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-splicing factor 1/SF1 Antibody catalog # PA1864. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human splicing factor 1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	68-80 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Splicing factor 1;Mammalian branch point-binding protein;BBP;mBBP;Transcription factor ZFM1;Zinc finger gene in MEN1 locus;Zinc finger protein 162;SF1;ZFM1, ZNF162;
Tissue Specificity	Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q15637
Gene Name	SF1
Sequence	Belongs to the BBP/SF1 family.
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Rat<br> Immunocytochemistry , 0.5-1ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Toda, T., Iida, A., Miwa, T., Nakamura, Y., Imai, T. Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1). Hum. Molec. Genet. 3: 465-470, 1994.<br /><br />2. Caslini, C., Spinelli, O., Cazzaniga, G., Golay, J., De Gioia, L., Pedretti, A., Breviario, F., Amaru, R., Barbui, T., Biondi, A., Introna, M., Rambaldi, A. Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins. Genomics 42: 268-277, 1997.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007122-1	PA1864	-	100 ug	$370		Add to Cart
BHA21007122-2	PA1864-10ug	Sample	10 ug	$99		Add to Cart
BHA21007122-3	PA1864-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007122-4	PA1864-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007122-5	PA1864-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007122-6	PA1864-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007122-7	PA1864-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007122-8	PA1864-FITC	FITC	100 ug	$570		Add to Cart
BHA21007122-9	PA1864-HRP	HRP	100 ug	$570		Add to Cart
BHA21007122-10	PA1864-APC	APC	100 ug	$670		Add to Cart
BHA21007122-11	PA1864-PE	PE	100 ug	$670		Add to Cart
BHA21007122-12	PA1864-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007122-13	PA1864-carrier-free	carrier-free	100 ug	$370		Add to Cart

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