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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SHP2/PTPN11 Antibody Picoband®

SKU : BHA21006665

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Mfr.No.	PA1114, PA1114-10ug, PA1114-Biotin, PA1114-Cy3, PA1114-Dylight488, PA1114-Dylight550, PA1114-Dylight594, PA1114-FITC, PA1114-HRP, PA1114-APC, PA1114-PE, PA1114-iFluor647, PA1114-carrier-free
Alternative Names	Tyrosine-protein phosphatase non-receptor type 11
Background	The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity. Shp2 can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation. Shp2 is specifically required in mesenchyme cells of the progress zone (PZ), ly beneath the distal ectoderm of the limb bud. Rather than integrating proliferative signals, Shp2 probably exerts its effects on limb development by influencing cell shape, movement or adhesion. Furthermore, the branchial arches, which also use Fgfs during bud outgrowth, similarly require Shp2. Thus, Shp2 regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SHP2/PTPN11 Antibody catalog # PA1114. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human SHP2, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	70-74 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tyrosine-protein phosphatase non-receptor type 11;3.1.3.48;Protein-tyrosine phosphatase 1D;PTP-1D;Protein-tyrosine phosphatase 2C;PTP-2C;SH-PTP2;SHP-2;Shp2;SH-PTP3;PTPN11;PTP2C, SHPTP2;
Tissue Specificity	Widely expressed, with highest levels in heart, brain, and skeletal muscle. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q06124
Gene Name	PTPN11
Sequence	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Saxton, T. M.; Ciruna, B. G.; Holmyard, D.; Kulkai, S.; Harpal, K.; Rossant, J.; Pawson, T. : The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development. Nature Genet. 24: 420-423, 2000.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006665-1	PA1114	-	100 ug	$370		Add to Cart
BHA21006665-2	PA1114-10ug	Sample	10 ug	$99		Add to Cart
BHA21006665-3	PA1114-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006665-4	PA1114-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006665-5	PA1114-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006665-6	PA1114-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006665-7	PA1114-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006665-8	PA1114-FITC	FITC	100 ug	$570		Add to Cart
BHA21006665-9	PA1114-HRP	HRP	100 ug	$570		Add to Cart
BHA21006665-10	PA1114-APC	APC	100 ug	$670		Add to Cart
BHA21006665-11	PA1114-PE	PE	100 ug	$670		Add to Cart
BHA21006665-12	PA1114-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006665-13	PA1114-carrier-free	carrier-free	100 ug	$370		Add to Cart

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