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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SHC/SHC1 Antibody Picoband®

SKU : BHA21007148

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Mfr.No.	PA1897, PA1897-10ug, PA1897-Biotin, PA1897-Cy3, PA1897-Dylight488, PA1897-Dylight550, PA1897-Dylight594, PA1897-FITC, PA1897-HRP, PA1897-APC, PA1897-PE, PA1897-iFluor647, PA1897-carrier-free
Alternative Names	SHC-transforming protein 1
Background	SHC1 (SHC-transforming protein 1), also known as SHCA, is a protein that in humans is encoded by the SHC1 gene. SCOP classifies the 3D structure as belonging to the SH2 domain family. By Southe analysis of somatic cell hybrids followed by both isotopic and fluorescence in situ hybridization, Huebner et al. (1994) assigned the SHC1 gene to 1q21. Yulug et al. (1995) used fluorescence in situ hybridization to map the SHC1 gene to 1q21. By the same method, an SHC-related sequence (SHCL1) was mapped to 17q21-q22. By FISH analysis and sequencing of vectorette library PCR products, Harun et al. (1997) identified SHC1P1, a 3.2-kb processed pseudogene, in Xq12-q13.1. SHC1P1 is 85% identical to mouse Shc p66. Reporter assays showed FKHRL1 transactivates CAT, suggesting a capacity to augment antioxidant scavenging. Nemoto and Finkel (2002) concluded that there is an important functional relationship between forkhead proteins (e.g., FKHRL1), SHC1, and intracellular oxidants, all of which are though to be involved in the aging process in worms and mammals.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SHC/SHC1 Antibody catalog # PA1897. Tested in IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosin
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human SHC, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	46 kDa, 52 kDa, 66 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	SHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;Src homology 2 domain-containing-transforming protein C1;SH2 domain protein C1;SHC1;SHC, SHCA;
Tissue Specificity	Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P29353
Gene Name	SHC1
Sequence	Contains 1 PID domain.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, IHC-F, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, -<br>Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Rat, Human, Mouse<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Harun, R. B., Smith, K. K., Leek, J. P., Markham, A. F., Norris, A., Morrison, J. F. J.Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1.Genomics 42: 349-352, 1997.<br /><br />2. Huebner, K., Kastury, K., Druck, T., Salcini, A. E., Lanfrancone, L., Pelicci, G., Lowenstein, E., Li, W., Park, S.-H., Cannizzaro, L., Pelicci, P. G., Schlessinger, J.Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).Genomics 22: 281-287, 1994.<br /><br />3. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Foi, G., Nicoletti, I., Grignani, F., Pawson, T., Pelicci, P. G.A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.Cell 70: 93-104, 1992.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007148-1	PA1897	-	100 ug	$370		Add to Cart
BHA21007148-2	PA1897-10ug	Sample	10 ug	$99		Add to Cart
BHA21007148-3	PA1897-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007148-4	PA1897-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007148-5	PA1897-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007148-6	PA1897-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007148-7	PA1897-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007148-8	PA1897-FITC	FITC	100 ug	$570		Add to Cart
BHA21007148-9	PA1897-HRP	HRP	100 ug	$570		Add to Cart
BHA21007148-10	PA1897-APC	APC	100 ug	$670		Add to Cart
BHA21007148-11	PA1897-PE	PE	100 ug	$670		Add to Cart
BHA21007148-12	PA1897-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007148-13	PA1897-carrier-free	carrier-free	100 ug	$370		Add to Cart

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