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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Sex Hormone Binding Globulin/SHBG Antibody Picoband®

SKU : BHA21000177

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Mfr.No.	PB9326, PB9326-10ug, PB9326-Biotin, PB9326-Cy3, PB9326-Dylight488, PB9326-Dylight550, PB9326-Dylight594, PB9326-FITC, PB9326-HRP, PB9326-APC, PB9326-PE, PB9326-iFluor647, PB9326-carrier-free
Alternative Names	Sex hormone-binding globulin
Background	Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones,androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Sex Hormone Binding Globulin/SHBG Antibody Picoband® catalog # PB9326. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic cl
Host	Rabbit
Immunogen Region	E.coli-derived human SHBG recombinant protein (Position: L30-A210). Human SHBG shares 72% amino acid (aa) sequence identity with both mouse and rat SHBG.
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sex hormone-binding globulin;SHBG;Sex steroid-binding protein;SBP;Testis-specific androgen-binding protein;ABP;Testosterone-estradiol-binding globulin;TeBG;Testosterone-estrogen-binding globulin;SHBG;
Tissue Specificity	Isoform 1 and isoform 2 are present in liver and testis.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P04278
Gene Id	6462
Gene Name	SHBG
Sequence	Contains 2 laminin G-like domains.
Subcellular Location	Secreted . In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Hammond GL (2011). "Diverse Roles for Sex Hormone-Binding Globulin in Reproduction". Biology of Reproduction 85(3): 431441. 2. Selva, D. M., Hogeveen, K. N., Innis, S. M., Hammond, G. L. Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J. Clin. Invest. 117: 3979-3987, 2007. 3. Simó R, Barbosa-Desongles A, Heandez C, Selva DM (November 2012). "IL1beta down-regulation of sex hormone-binding globulin production by decreasing HNF-4alpha via MEK-1/2 and JNK MAPK pathways". Mol. Endocrinol. 26 (11): 191727.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000177-1	PB9326	100 ug	-	$370		Add to Cart
BHA21000177-2	PB9326-10ug	10 ug	Sample	$99		Add to Cart
BHA21000177-3	PB9326-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000177-4	PB9326-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000177-5	PB9326-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000177-6	PB9326-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000177-7	PB9326-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000177-8	PB9326-FITC	100 ug	FITC	$570		Add to Cart
BHA21000177-9	PB9326-HRP	100 ug	HRP	$570		Add to Cart
BHA21000177-10	PB9326-APC	100 ug	APC	$670		Add to Cart
BHA21000177-11	PB9326-PE	100 ug	PE	$670		Add to Cart
BHA21000177-12	PB9326-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000177-13	PB9326-carrier-free	100 ug	carrier-free	$370		Add to Cart

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