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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RUNX2 Antibody Picoband®

SKU : BHA21006687

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Mfr.No.	PA1224, PA1224-10ug, PA1224-Biotin, PA1224-Cy3, PA1224-Dylight488, PA1224-Dylight550, PA1224-Dylight594, PA1224-FITC, PA1224-HRP, PA1224-APC, PA1224-PE, PA1224-iFluor647, PA1224-carrier-free
Alternative Names	Runt-related transcription factor 2
Background	Core binding factor A1 (CBFA1/RUNX2) is a runt-like transcription factor essential for osteoblast differentiation. This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. D'Souza et al. (1999) indicate a non-redundant role for Cbfa1 in tooth development that may be distinct from that in bone formation. In odontogenesis, Cbfa1 is not involved in the early signaling networks regulating tooth initiation and early morphogenesis but regulates key epithelial-mesenchymal interactions that control advancing morphogenesis and histodifferentiation of the epithelial enamel organ.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-RUNX2 Antibody catalog # PA1224. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhan
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human RUNX2, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	62 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Runt-related transcription factor 2;Acute myeloid leukemia 3 protein;Core-binding factor subunit alpha-1;CBF-alpha-1;Oncogene AML-3;Osteoblast-specific transcription factor 2;OSF-2;Polyomavirus enhancer-binding protein 2 alpha A subunit;PEA2-alpha A;PEBP2-alpha A;SL3-3 enhancer factor 1 alpha A subunit;SL3/AKV core-binding factor alpha A subunit;RUNX2;AML3, CBFA1, OSF2, PEBP2A;
Tissue Specificity	Specifically expressed in osteoblasts.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q13950
Gene Name	RUNX2
Sequence	Contains 1 Runt domain.
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Bergwitz, C.; Prochnau, A.; Mayr, B.; Kramer, F.-J.; Rittierodt, M.; Berten, H.-L.; Hausamen, J.-E.; Brabant, G. : Identification of novel CBFA1/RUNX2 mutations causing cleidocranial dysplasia. J. Inherit. Metab. Dis. 24: 648-656, 2001. <br /><br />2. D'Souza, R. N.; Aberg, T.; Gaikwad, J.; Cavender, A.; Owen, M.; Karsenty, G.; Thesleff, I. : Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126: 2911-2920, 1999.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006687-1	PA1224	-	100 ug	$370		Add to Cart
BHA21006687-2	PA1224-10ug	Sample	10 ug	$99		Add to Cart
BHA21006687-3	PA1224-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006687-4	PA1224-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006687-5	PA1224-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006687-6	PA1224-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006687-7	PA1224-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006687-8	PA1224-FITC	FITC	100 ug	$570		Add to Cart
BHA21006687-9	PA1224-HRP	HRP	100 ug	$570		Add to Cart
BHA21006687-10	PA1224-APC	APC	100 ug	$670		Add to Cart
BHA21006687-11	PA1224-PE	PE	100 ug	$670		Add to Cart
BHA21006687-12	PA1224-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006687-13	PA1224-carrier-free	carrier-free	100 ug	$370		Add to Cart

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