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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RIP/RIPK1 Antibody Picoband®

SKU : BHA21007265

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Mfr.No.	PA2051, PA2051-10ug, PA2051-Biotin, PA2051-Cy3, PA2051-Dylight488, PA2051-Dylight550, PA2051-Dylight594, PA2051-FITC, PA2051-HRP, PA2051-APC, PA2051-PE, PA2051-iFluor647, PA2051-carrier-free
Alternative Names	Receptor-interacting serine/threonine-protein kinase 1
Background	RIPK1 (Regulator of G Protein Signaling 3), also called RIP, is an enzyme that in humans is encoded by the RIPK1 gene. Members of the TRAF protein family have been implicated in the activation of NF-kappa-B by the TNF superfamily. By yeast 2-hybrid and coimmunoprecipitation studies using mammalian cell extracts, Hsu et al. (1996) showed that RIP interacts with TRADD, TRAF1, TRAF2, and TRAF3. Hartz (2012) mapped the RIPK1 gene to chromosome 6p25.2 based on an alignment of the RIPK1 sequence with the genomic sequence. Stanger et al. (1995) found that overexpression of Rip in mammalian cells induced morphologic changes characteristic of apoptosis. They suggested that RIP may be an important element in the signal transduction machinery that mediates programmed cell death.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-RIP/RIPK1 Antibody catalog # PA2051. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cy
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human RIP.
Isotype	Rabbit IgG
Molecular Weight	76 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Receptor-interacting serine/threonine-protein kinase 1;2.7.11.1;Cell death protein RIP;Receptor-interacting protein 1;RIP-1;Serine/threonine-protein kinase RIP;RIPK1;RIP, RIP1;
Tissue Specificity	Detected in embryos from E8.5-16.5 in cortical ventricular zone, dorsal root ganglia and cerebellar primordia. Isoform 3 is detected in testis and in spermatocytes from newbo mice. Levels increase and reach a maximum after 21 days; after this they decrease again. Long isoforms are widely expressed. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q13546
Gene Name	RIPK1
Sequence	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Subcellular Location	Cytoplasm. Cell membrane .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Hartz, P. A. Personal Communication. Baltimore, Md. 10/26/2012. <br /><br />2. Hsu, H., Huang, J., Shu, H.-B., Baichwal, V., Goeddel, D. V. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387-396, 1996. <br /><br />3. Stanger, B. Z., Leder, P., Lee, T.-H., Kim, E., Seed, B. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81: 513-523, 1995.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007265-1	PA2051	-	100 ug	$370		Add to Cart
BHA21007265-2	PA2051-10ug	Sample	10 ug	$99		Add to Cart
BHA21007265-3	PA2051-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007265-4	PA2051-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007265-5	PA2051-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007265-6	PA2051-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007265-7	PA2051-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007265-8	PA2051-FITC	FITC	100 ug	$570		Add to Cart
BHA21007265-9	PA2051-HRP	HRP	100 ug	$570		Add to Cart
BHA21007265-10	PA2051-APC	APC	100 ug	$670		Add to Cart
BHA21007265-11	PA2051-PE	PE	100 ug	$670		Add to Cart
BHA21007265-12	PA2051-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007265-13	PA2051-carrier-free	carrier-free	100 ug	$370		Add to Cart

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