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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RANKL/TNFSF11 Antibody Picoband®

SKU : BHA21000920

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Mfr.No.	PB10015, PB10015-10ug, PB10015-Biotin, PB10015-Cy3, PB10015-Dylight488, PB10015-Dylight550, PB10015-Dylight594, PB10015-FITC, PB10015-HRP, PB10015-APC, PB10015-PE, PB10015-iFluor647, PB10015-carrier-free
Alternative Names	Tumor necrosis factor ligand superfamily member 11
Background	Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. It is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-RANKL/TNFSF11 Antibody Picoband® catalog # PB10015. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells an
Host	Rabbit
Immunogen Region	E. coli-derived rat RANKL recombinant protein (Position: F141-D318). Rat RANKL shares 87.9% and 96.6% amino acid (aa) sequence identity with human and mouse RANKL, respectively.
Isotype	Rabbit IgG
Molecular Weight	40 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor ligand superfamily member 11;Osteoclast differentiation factor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-B ligand;RANKL;TNF-related activation-induced cytokine;TRANCE;CD254;Tumor necrosis factor ligand superfamily member 11, membrane form;Tumor necrosis factor ligand superfamily member 11, soluble form;Tnfsf11;Opgl, Rankl, Trance;
Tissue Specificity	Highly expressed in thymus and bone tissues.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9ESE2
Gene Id	117516
Gene Name	Tnfsf11
Sequence	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
Subcellular Location	Cell membrane ; Single-pass type II membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	ELISA, 0.1-0.5ug/ml, -, Rat Weste blot, 0.1-0.5ug/ml, Rat

Reference	1. Asselin-Labat, M.-L., Vaillant, F., Sheridan, J. M., Pal, B., Wu, D., Simpson, E. R. Yasuda, H.; Smyth, G. K.; Martin, T. J.; Lindeman, G. J.; Visvader, J. E.: Control of mammary stem cell function by steroid hormone signalling. Nature 465: 798-802, 2010. 2. Luan, X., Lu, Q., Jiang, Y., Zhang, S., Wang, Q., Yuan, H., Zhao, W., Wang, J., Wang, X.Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J Immun. 189: 245-252, 2012.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000920-1	PB10015	100 ug	-	$370		Add to Cart
BHA21000920-2	PB10015-10ug	10 ug	Sample	$99		Add to Cart
BHA21000920-3	PB10015-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000920-4	PB10015-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000920-5	PB10015-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000920-6	PB10015-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000920-7	PB10015-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000920-8	PB10015-FITC	100 ug	FITC	$570		Add to Cart
BHA21000920-9	PB10015-HRP	100 ug	HRP	$570		Add to Cart
BHA21000920-10	PB10015-APC	100 ug	APC	$670		Add to Cart
BHA21000920-11	PB10015-PE	100 ug	PE	$670		Add to Cart
BHA21000920-12	PB10015-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000920-13	PB10015-carrier-free	100 ug	carrier-free	$370		Add to Cart

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