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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RAGE/AGER Antibody Picoband®

SKU : BHA21006650

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Mfr.No.	PA1069, PA1069-10ug, PA1069-Biotin, PA1069-Cy3, PA1069-Dylight488, PA1069-Dylight550, PA1069-Dylight594, PA1069-FITC, PA1069-HRP, PA1069-APC, PA1069-PE, PA1069-iFluor647, PA1069-carrier-free
Alternative Names	Advanced glycosylation end product-specific receptor
Background	The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-RAGE/AGER Antibody catalog # PA1069. Tested in IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human RAGE, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	43 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Advanced glycosylation end product-specific receptor;Receptor for advanced glycosylation end products;AGER;RAGE;
Tissue Specificity	Endothelial cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q15109
Gene Name	AGER
Sequence	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, IHC-F, WB
Description	Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, By Heat<br>Weste blot, 0.1-0.5ug/ml<br>

Reference	1. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, Hofmann MA, Kislinger T, Ingram M, Lu A, Tanaka H, Hori O, Ogawa S, Ste DM, Schmidt AM. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature.2000 May 18; 405(6784):354-60.<br /><br />2. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Ste D, Schmidt AM. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25; 97(7):889-901.<br /><br />3. Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG, Schulz JB, Heuss D, Neundorfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Haering HU, Schleicher E, Kasper M, Ste DM, Aold B, Nawroth PP. Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest. 2004 Dec; 114(12):1741-51.<br /><br />4. Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Aold B, Preissner KT, Nawroth PP. The patte recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment. J Exp Med. 2003 Nov 17; 198(10):1507-15.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006650-1	PA1069	-	100 ug	$370		Add to Cart
BHA21006650-2	PA1069-10ug	Sample	10 ug	$99		Add to Cart
BHA21006650-3	PA1069-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006650-4	PA1069-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006650-5	PA1069-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006650-6	PA1069-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006650-7	PA1069-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006650-8	PA1069-FITC	FITC	100 ug	$570		Add to Cart
BHA21006650-9	PA1069-HRP	HRP	100 ug	$570		Add to Cart
BHA21006650-10	PA1069-APC	APC	100 ug	$670		Add to Cart
BHA21006650-11	PA1069-PE	PE	100 ug	$670		Add to Cart
BHA21006650-12	PA1069-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006650-13	PA1069-carrier-free	carrier-free	100 ug	$370		Add to Cart

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